There will be more joy for Southampton at Villa, so cash in by backing them to win 3-0, with Graziano Pelle to score the first goal.
Spurs are a different proposition without any midweek Europa League action so back them to win 2-0, with Erik Lamela to score first.
Back Liverpool to exorcise the Selhurst Park ghosts of last season, with Emre Can a good tip to score first and inspire a 3-0 victory.
Another win will be a bridge too far for Burnley, so back Stoke to triumph 2-0, with Peter Crouch a good pick to break the deadlock.
The smart money is on a Newcastle win against QPR, let's say 2-1, but cover yourself by backing in-form Charlie Austin to bag opener.
Despite their troubles, you would be foolish to back against Man City at home, so go big on Sergio Aguero to score first in 2-0 win.
The obvious bet points towards a draw here, so recoup some profit by backing Sunderland's Steven Fletcher to score first in a 1-1 draw.
Everton and West Ham's good runs will continue after a 1-1 draw, with Andy Carroll looking a good bet to score first for the Hammers.
Jose Mourinho's side will be fancied to preserve their unbeaten record and you cannot ignore Diego Costa to score first in a 3-0 win.
Arsenal against United games are notoriously tight so backing 1-1 draw is sensible, with Danny Welbeck to score against former club.
With five goals in as many games, Saido Berahino is a safe bet to open the scoring for West Brom in a 1-1 draw with Newcastle.
Tottenham won't have it all their own way here but expect another 2-1 victory against Stoke with Christian Eriksen opening the scoring.
Alexis Sanchez has scored five in three but a goal this time may only be enough to secure Arsenal a 2-2 draw at the Liberty Stadium.
Everton romped to a 3-1 win at Burnley in their last away game and expect the same result here, with Samuel Eto'o breaking deadlock.
In-form Diafra Sakho, likely to return to action after injury, looks a smart bet to score first in a comfortable 2-0 win for West Ham.
Southampton are expected to keep the pressure on leaders Chelsea with a 3-0 victory, the prolific Graziano Pelle opening the scoring.
Argentinian striker Sergio Aguero looks good value to continue his red-hot streak with the only goal for the second successive weekend.
Manchester United have fresh problems in defence but they will have enough to see off Palace in a 3-0 win, Wayne Rooney scoring first.
This will be a close one but back unbeaten Chelsea to claim a 2-1 success against Liverpool at Anfield and Oscar to grab opening goal.