Mark Noble, who is available after having his red card at Liverpool rescinded, will fire the opener as West Ham stroll to a 3-1 win.
Riyad Mahrez, who has made an impressive start to season, will get only goal as Leicester secure victory at the King Power Stadium.
England striker Harry Kane will set Spurs on their way to three points with the opening goal in a 2-1 victory at the Stadium of Light.
Expect Wayne Rooney to follow up his record-breaking England goal in midweek by netting opener as United prevail 2-1 at Old Trafford.
Nothing will separate the sides as they battle out a goalless draw at The Hawthorns as their starts to the season remain inconsistent.
Bafetimbi Gomis will continue his run of scoring in every game this season by putting Swansea on the way to a hard-fought 2-1 victory.
Cameron Jerome will open his account for the season as the Canaries record a 2-1 victory at Carrow Road to get off the mark at home.
A clash of ambitions will see clubs cancel each other out with Sergio Aguero, with opener, and Jason Puncheon scoring in a 1-1 draw.
Don't expect the Potters' luck to turn with Alexis Sanchez set to break his duck for new term with a brace in a 3-1 Arsenal victory.
Last year this fixture yielded nine goals, Chelsea winning 6-3. But Romelu Lukaku will score opener against his former club in 2-1 win.
Liverpool's defence will finally be breached but the dangerous Philippe Coutinho will be on scoresheet in a 2-1 win over the Hammers.
Andre Ayew has settled in well at Swansea and will be on target first as the Welsh side hold Manchester United to a 1-1 draw on Sunday.
This looks the ideal time for Norwich to travel to St Mary's and Cameron Jerome can be on target first in a 2-1 win for the Canaries.
Spurs and Everton both hope to push for a European place this season and will cancel each other out in a 0-0 draw at White Hart Lane.
It promises to be an unhappy return to Stoke for Albion boss Tony Pulis as Xherdan Shaqiri's opens his Potters account in a 2-0 win.
Arsenal need to get going quickly and will be grateful to have a match-winner like Alexis Sanchez as they hold on for a 2-1 win.
The trip to the Etihad is a step up in difficulty for Watford and they will have no answer to Sergio Aguero in a 4-0 City victory.
Chelsea will miss suspended captain John Terry and will be frustrated in a 1-1 draw after Bakary Sako's opener for Crystal Palace.
Both teams will be confident but last week's hat-trick hero Callum Wilson can score first in 2-1 win for Bournemouth over Leicester.