Adam Lallana, who impressed on England duty in midweek, will fire Saints back to winning ways with the only goal at Selhurst Park.
The Blues have dropped just four points at home all season and the in-form Eden Hazard will put them on the way to a 2-0 success.
A point will do neither side any good but that is what they will have to settle for in a drab goalless stalemate in south Wales.
Norwich's home record will again stand them in good stead as Jonny Howson, who scored in earlier meeting between sides, nets only goal.
Baggies have held Everton, Liverpool and Chelsea to 1-1 draws at home and they will add United to list, Robin van Persie scoring first.
Tim Sherwood's Spurs will bounce back in style with a convincing 3-0 victory at White Hart Lane, with Paulinho firing them in front.
Swans will make it three victories in row at home as they secure a 2-1 triumph, Wilfried Bony nudging them in front at Liberty Stadium.
Aston Villa's wait for a victory will continue as the Canaries earn a 1-1 draw at Villa Park, Bradley Johnson having put them ahead.
Luis Suarez has gone four games without goal but will be back on scoresheet as Liverpool maintain their good form by claiming 2-1 win.
Potters have beaten Chelsea and Man Utd at home but they will have to settle for a 1-1 draw, Peter Crouch having fired them in front.
Hull's home form has dipped recently but they will get back to winning ways at KC Stadium, Shane Long opening scoring in a 2-1 victory.
Chelsea have taken 11 points from last 15 on the road and should have too much for Fulham, with Eden Hazard netting first in a 2-0 win.
The Toffees are strong at home and will record a fourth straight win at Goodison Park, Steven Pienaar scoring first in a 2-1 triumph.
The Canaries are generally hard to beat at Carrow Road and they will pick up a vital point, with Leroy Fer nudging them in front.
A lack of goals will again be the order of the day, with both having to settle for point from a goalless stalemate at St James' Park.
Liverpool will make it a 12th home win in league this term by showing Swansea no mercy, Luis Suarez putting them on way to 3-0 victory.
Arsenal will not have it all their own way against Sunderland, with Alex Oxlade-Chamberlain's solitary strike separating the two teams.
Ole Gunnar Solskjaer's Cardiff can get back to winning ways, with former Tigers striker Fraizer Campbell scoring first in 2-1 victory.
Expect another routine 3-0 victory for Manuel Pellegrini's side against Stoke, with midfield playmaker David Silva breaking deadlock.