Swansea will be keen to take advantage of Hull’s travel sickness here, with Jonathan de Guzman due a third goal of season in 2-0 win.
Fulham still look shaky at back so Villa are value bet to make it four away wins with 2-1 success, Gabriel Agbonlahor scoring first.
If Arsenal can take their chances they are fancied to prevail 2-1 against buoyant Everton, with Aaron Ramsey continuing to get forward.
With home advantage, West Brom are taken to run out 3-1 winners against Norwich, with striker Saido Berahino adding to his six goals.
Sunderland are improving going forward but still look vulnerable at back, with Jermain Defoe taken to hit the target in a 2-1 away win.
Chelsea can further enhance their fine record against Stoke with a 2-1 success, with Eden Hazard worth following for first scorer.
Manchester City are fancied to shade a shell-shocked Saints outfit 2-1, with Alvaro Negredo netting first after being rested midweek.
These are testing times for Man Utd, so this may be Newcastle’s chance to end Old Trafford hoodoo, with Loic Remy netting in a 2-1 win.
Liverpool have been pretty ruthless at Anfield of late, so stick with in-form Luis Suarez to lead the way again in a 3-0 home victory.
Go for tight stalemate here, with midweek goalscorer Marouane Chamakh a tentative tip to score first for Palace if deadlock is broken.
Chelsea are good value to win at Sunderland for the sixth consecutive season, with midfielder Frank Lampard netting in a 2-1 victory.
Stoke have only let in three goals in six home games and can get back on track with a 2-0 win over Cardiff, Peter Crouch scoring first.
Fulham, despite a change in boss, look there for the taking and Tottenham get the nod to prevail 2-1, Roberto Soldado finding the net.
Norwich have lost five of six away games so go with Liverpool to triumph 2-0 and Luis Suarez the obvious pick to break the deadlock.
Hull have struggled away and Arsenal are expected to stay ahead of the chasing pack with a 3-0 win, with Olivier Giroud to score first.
Swansea did the double over Newcastle last term but the visitors have improved so expect a 1-1 draw, with Jonjo Shelvey netting first.
Manchester City need to improve their results on the road and are fancied to beat West Brom 3-1 with Samir Nasri finding the net first.
Southampton are looking to bounce back against Aston Villa, with England striker Rickie Lambert fancied to fire his side to a 2-0 win.
David Moyes will be determined to put one over his ex-club Everton, with Manchester United taken to prevail 3-1 and Nani scoring first.