Stoke will finally get their first win at the Britannia as Peter Crouch will open the scoring against Newcastle in a 2-0 success.
There will be little to separate West Brom and Burnley, with both teams having to settle for a point apiece in a goalless stalemate.
Garry Monk's Swansea side will claim a 2-1 win at Sunderland, with Bafetimbi Gomis – in for suspended Wilfried Bony – opening scoring.
This should be a straightforward win for an impressive Southampton side, so go for 2-0 and Dusan Tadic to break deadlock against QPR.
Man Utd dismantled QPR in their last match and although this will be closer against West Ham, back Angel Di Maria to score in 3-1 win.
Expect this all-Merseyside clash to be tight, with Mario Balotelli marking his first derby with a goal in a 1-1 draw against Everton.
Steve Bruce's Hull will be left waiting for a first home win as Man City striker Edin Dzeko will score twice in 3-1 win at KC Stadium.
Leicester's Leonardo Ulloa could take advantage of Palace defence that has shipped 10 league goals already to score first in a 2-1 win.
Diego Costa will be looking to return to goalscoring ways at Villa and back him to set in-form Chelsea on their way to a 2-0 victory.
Alexis Sanchez will mark his first north London derby with opener as Arsenal pile more pressure on bitter rivals Spurs with a 3-1 win.
Tottenham look too strong for West Brom and should notch a home win, with in-form Nacer Chadli breaking the deadlock in a 3-0 victory.
This could be a classic but back Eden Hazard to break the deadlock for Chelsea in 2-1 win for the unbeaten visitors against champions.
Angel di Maria can inspire Manchester United to a 3-2 win in a lively game at Leicester, with Wayne Rooney a good bet to score first.
Expect a comfortable victory for Everton in this one, with Kevin Mirallas adding to his goal against West Brom with opener in 3-0 win.
Raheem Sterling should be restored to the starting line-up and he will have too much for West Ham as he opens the scoring in a 3-1 win.
Expect the points to be shared in a 1-1 draw with new recruit Graziano Pelle scoring for Southampton for the fourth successive match.
Peter Crouch will open the scoring with his first league goal of the season as Stoke make it back-to-back away wins with a 2-1 success.
Striker Abel Hernandez looks a decent shout to open the scoring for Hull but the game at Newcastle will finish all square at 1-1.
It is expected to be a tight game at Turf Moor but back Burnley striker Danny Ings to open his account for the season in a 1-1 draw.