United are the favourites to continue their run of form in this one. To make money choose Antonio Valencia to bag first in a 3-1 win.
Stoke's three-game unbeaten run will end against Arsenal at the Emirates, so back Alexis Sanchez to score first in a routine 3-0 win.
Liverpool’s lack of creativity remains a problem and they will struggle to break down Swansea’s stubborn defence in a goalless draw.
It is at White Hart Lane that Spurs have struggled the most and Wayne Rooney can make it six goals in seven games in a 2-1 United win.
Stoke have only lost one of their last 15 meetings with West Brom and Jonathan Walters can set them on their way to another 2-0 win.
Saints have struggled against their expected top-four rivals which suggests Chelsea can edge this 1-0 thanks to a Diego Costa winner.
QPR have scored at least two goals in each of their last seven home games and that can continue as Charlie Austin nets in a 3-1 win.
Both teams will be desperate to end their losing runs and Newcastle start slowly so expect Romelu Lukaku to score first in a 1-1 draw.
There is nothing to suggest Burnley can end the run of City, who should be comfortable 3-0 winners after David Silva nets the opener.
Hull should have extra confidence after ending a 10-match winless run and Nikica Jelavic can set them on their way to a 2-0 victory.
Just one point separates these teams but expect Villa to extend their advantage, with Christian Benteke scoring in a 1-0 home victory.
The form guide suggests plenty of goals in this London derby and Hammers striker Andy Carroll can get the first of them in a 2-2 draw.
Back Chelsea to come through a tricky test with flying colours with a 2-0 win, Oscar the stand-out choice in the first-scorer market.
The smart money would be on another draw here and this Tyne-Wear derby could very well be a poor goalless affair.
Things could get a whole lot worse for Liverpool here, with Danny Welbeck a solid pick to score first in 2-0 win for resurgent Arsenal.
Everton need to put a run together to threaten the European places and 2-0 win over QPR will be a start, Kevin Mirallas scoring first.
Swansea play with confidence at the Liberty and that will be enhanced by a 2-1 victory which is kicked off by Wilfried Bony's opener.
This crunch clash comes at a good time for United and Wayne Rooney will start the scoring as they earn bragging rights with a 2-0 win.
Backing Southampton's flop to continue would be a sensible move, with Robin van Persie good value to notch first in 3-1 win on Monday.